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Using firefly liquid dealing with for laboratory developed checks

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Using firefly liquid dealing with for laboratory developed checks

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In relation to automated liquid dealing with, what are the important components for achievement in high-throughput CLIA-certified laboratories providing Laboratory-Developed Assessments (LDTs), particularly within the context of next-generation sequencing (NGS) library preparation?

Success in high-throughput laboratories providing LDTs hinges on just a few key components. Firstly, reliability is paramount. Laboratories want to have the ability to depend on their devices for constant and correct outcomes. The second essential issue is ease of use. This encompasses each day-to-day operation (that’s, environment friendly setup and minimal error danger), in addition to the power to develop and implement new checks with ease. That is particularly essential for NGS purposes as they turn into extra advanced and prevalent. The method that we have now taken with firefly improvement emphasizes our need for patrons to face on their very own two toes and have the ability to develop and optimize new strategies with much less reliance on vendor assist.

Moreover, the power to miniaturize checks is a sport changer on this cost-sensitive market. Through the use of expertise that helps dependable and correct miniaturization, laboratories can cut back reagent volumes and prices, thereby making checks extra worthwhile for medical diagnostics.

How are SPT Labtech’s automated liquid dealing with options designed to assist medical laboratory wants?

Our automated liquid dealing with options are constructed on strong, progressive expertise developed by our main scientists and engineers. Central to our method is a dedication to collaboration, each inside our group and with our prospects. We actively have interaction with the scientific group, tuning in to laboratories’ real-world challenges. That is why scientists and researchers worldwide belief us to develop distinctive, personalised options. By drawing on experience from inside our workforce, we innovate to fulfill a acknowledged want and take that concept to market.

Particularly specializing in firefly, we have now carried out customer-driven improvements that improve its performance and consumer expertise. Amongst these is the power for customers to simply create and develop their strategies by an intuitive consumer interface for easy day by day operation. Our software program platform prioritizes usability in technique improvement and consumer operation, providing totally different entry ranges for outlined customers, from easy technique execution to superior automation management.

Image Credit: SPT LabtechPicture Credit score: SPT Labtech

What function did automated liquid handlers, like dragonfly® discovery, play through the pandemic response for LDT laboratories?

Automated liquid handlers performed a major function through the pandemic. The worldwide scarcity of pipette suggestions and the demand for large-scale testing drove consciousness of the advantages of reagent dispensers together with conventional liquid dealing with devices.

dragonfly discovery’s non-contact reagent shelling out functionality helped to preserve key sources and expedite protocols, because it was used to dispense grasp mixes and extraction reagents day by day. It was instrumental in miniaturizing processes at scale, particularly to assist complete genome sequencing in variant detection.

Are you able to elaborate on how firefly’s liquid dealing with capabilities are utilized in NGS library preparation for LDTs and its adaptability to totally different workflows?

The important thing distinction with firefly in comparison with conventional automated liquid handlers is the sheer quantity of performance inside a single benchtop instrument. It combines the strong and dependable reagent shelling out of dragonfly discovery with a multi-functional pipette head, permitting for environment friendly and fast reagent distribution, minimal use of deck house, and lowered pipette tip utilization. This distinctive twin functionality makes firefly notably adept at NGS library preparation, which contains shelling out steps equivalent to bulk reagent, grasp combine, or ethanol addition, in addition to liquid switch steps for bead cleanups and index additions.

Moreover, firefly encompasses a gripping module that facilitates automated plate motion throughout the system. No guide intervention is required to switch plates between deck positions, or on and off heaters, shakers, and magnets.

We’ll launch a brand new firefly+ module early subsequent 12 months, that includes an on-deck thermocycler and additional deck capability that gives a real walkaway resolution for NGS library preparation. For laboratories to function at most effectivity, customers can have entry to firefly’s full liquid dealing with capabilities whereas the thermocycler is in operation. This flexibility permits laboratories to make use of firefly in probably the most useful method to clear up their particular purposes and throughput necessities.

How does firefly’s compact design handle house constraints confronted by medical laboratories, and the way does it assist NGS-based LDTs?

Addressing house constraints has at all times been a main consideration in firefly‘s design, as laboratory house is at a premium for medical and analysis laboratories. We’re seeing that laboratories are sometimes needing to broaden their capabilities with new gear, and actual property is pricey, notably within the hubs the place a variety of medical laboratories are situated.

firefly’s compact footprint, achieved by using vertical house, permits it to suit extra functionalities in a smaller space than conventional massive deck liquid handlers. This compactness is additional enhanced because the system is operated completely from an built-in touchscreen, which means that there isn’t a want for added on-bench laptop gear.

May you share any insights into latest firefly software program updates that assist the wants of LDT laboratories?

From the outset, we have now targeted firefly software program improvement round enhancing consumer expertise, to facilitate safe and intuitive operation. We wished to make firefly capabilities accessible to all customers, and never simply these with in-house programming specialists.

The consumer entry management function presents various entry ranges, from primary technique working to finish automation interface management. Protocol model management and a full audit log of timestamped consumer logins and protocol runs guarantee traceability, which is important for the regulated atmosphere of laboratories providing LDTs. A barcode monitoring functionality for reagent and pattern plates is being developed, supporting unambiguous identification and dealing with.

One other key side of firefly is cloud-based protocol sharing, guaranteeing standardization of protocols throughout a number of laboratories and customers, making it straightforward for laboratories to breed and scale confidently.

How is firefly prepared to be used in regulated environments?

We introduced Denise Grovewood into our workforce as Diagnostics Undertaking Supervisor to make sure that we have now the mandatory methods in place to assist the wants of shoppers providing or growing LDTs. Denise has direct expertise working in diagnostics, as earlier than becoming a member of SPT Labtech, she supported constructing and working the gear division for mass COVID-19 testing within the UK. Denise has been integral since becoming a member of, supporting in coaching our software scientists to allow them to help prospects successfully.

firefly software program has been developed to fulfill compliance in diagnostics settings, with options we have now already coated, together with outlined consumer entry management, complete audit logs, and the power to get well runs.

Contemplating the present panorama, why is utilizing firefly for LDT so essential?

firefly’s significance within the present panorama is pushed primarily by its software in medical genomics, together with oncology, uncommon ailments, and reproductive well being. We’re already seeing the influence of NGS in most cancers diagnostics and companion therapies, and this expertise will proceed to be crucial in bettering affected person outcomes by optimum remedy choice, illness monitoring, and even early-stage illness detection. As NGS purposes develop, so does the necessity for scalable, worthwhile automation, which firefly addresses. It has been developed to adapt to those contexts’ rising pattern numbers and throughput necessities.

How do you see the function of firefly evolving and supporting the rising complexity of genomic sequencing and precision drugs in LDTs?

firefly is conceptualized as a dynamic platform product, engineered to evolve with the calls for of genomic sequencing and personalised drugs with continued developments in each its {hardware} and software program. We anticipate a rising development within the want for increased throughput and an elevated emphasis on unattended, walk-away operational capabilities, underpinned by a give attention to profitability for the laboratories performing these providers. In precision drugs, the velocity at which you’ll course of and interpret outcomes is important to bettering affected person outcomes. Introducing an on-deck thermocycler in firefly+ is the primary evolution of the present structure and illustrates our dedication to assembly the demand for elevated throughput and stroll away.

One other key side of firefly is the strategic give attention to miniaturization. By transitioning from 96 to 384-well plate processing, firefly allows laboratories to quadruple their pattern processing capability throughout the identical spatial footprint. This amplifies throughput and reduces consumables and reagents’ consumption, placing a steadiness between driving productiveness and price effectivity.

About Joby Jenkins

With over 20 years of expertise, initially as a part of the TTP group after which with SPT Labtech, Joby has established SPT Labtech as an internationally acknowledged supplier of cutting-edge devices and applied sciences for all times science analysis. 

Joby and his groups (product administration, purposes, and advertising) outline the corporate’s product technique by working carefully with extremely strategic and business companions to ship merchandise that clear up real-world challenges within the laboratory.

About SPT Labtech

SPT Labtech designs and manufactures strong, dependable, and easy-to-use options for all times science. We allow life scientists by collaboration, deep software information, and main engineering to speed up analysis and make a distinction collectively. We provide a portfolio of merchandise inside pattern administration, liquid dealing with, and multiplexed detection that reduce assay volumes, cut back materials dealing with prices, and put the invention instruments again within the fingers of the scientist.

On the coronary heart of what we do

A lot of our improvements have been born out of the need to create options to current buyer issues; and it’s this ethos that drives SPT Labtech’s R&D efforts. Our strengths come from the belief our prospects have with us to develop actually distinctive, automated applied sciences to fulfill their wants. We mix cutting-edge science with first-rate engineering to place prospects on the coronary heart of every part we do.

An issue-solving mind-set

The substantial breadth of experience inside our firm allows us to be concerned within the full life cycle of our merchandise from the preliminary design idea, mechanical and software program engineering, and prototyping, to ultimate manufacture and sale. These qualities permit us to supply the very best technical and mechanical assist to all of the gear that we provide, therefore sustaining wonderful consumer relationships.


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