Home Men's Health Use of blood fat-lowering statins linked to slower development of Alzheimer’s dementia

Use of blood fat-lowering statins linked to slower development of Alzheimer’s dementia

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Use of blood fat-lowering statins linked to slower development of Alzheimer’s dementia

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Blood fat-lowering statins might gradual the development of Alzheimer’s illness, a minimum of for some sufferers. That is the results of a brand new examine led by Karolinska Institutet printed in Alzheimer Analysis and Remedy. However the researchers are cautious of their interpretations and see the outcomes as a primary step in a analysis journey which will ultimately present the reply.

A brand new examine reveals that individuals with Alzheimer’s dementia deteriorated extra slowly of their cognitive features in the event that they had been additionally handled with a lipid-lowering statin, in comparison with those that weren’t handled. Nonetheless, the examine is an observational examine the place the researchers have in contrast knowledge on the sufferers from a registry and due to this fact can’t reply whether or not there actually is a causal relationship. Thus, the researchers are cautious of their interpretations.

Folks with Alzheimer’s dementia handled with statins had higher cognitive growth over time. Nonetheless, the outcomes of the examine don’t imply that we now have proof that individuals with dementia needs to be handled with statins. However however, we won’t see any assist for not doing so. So, if an individual wants statins for prime blood lipids, a dementia prognosis mustn’t cease the therapy.”


Sara Garcia-Ptacek, Affiliate Professor of Neuroscience and Affiliate Senior Lecturer on the Division of Neurobiology, Care Sciences and Society, and analysis chief of the present examine

The rationale she emphasizes security is that statins had been initially suspected of inflicting confusion in sufferers with dementia. There has due to this fact been some resistance to prescribing statins to those sufferers.

The examine included knowledge from greater than 15 500 sufferers with dementia who additionally had a sign for lipid-lowering therapy. Virtually 11 000 of them had been handled with statins. Typically, the sufferers who had been handled with statins had barely larger values within the cognitive assessments carried out, although they had been extra prone to have diagnoses equivalent to hypertension, heart problems and diabetes, all of that are danger components for dementia.

Sara Garcia-Ptacek explains that the analysis group began with a speculation that statins might gradual the development of dementia and solid a reasonably extensive internet to see if they might discover proof of this.

“The fundamental thought of this examine was to pave the way in which for a extra exact cohort examine that would ultimately result in a medical intervention examine, which is what is required to show a causal hyperlink between statins and cognition,” says Sara Garcia-Ptacek.

The concept statins might have an effect on the danger or development of dementia just isn’t new. There are even some medical research completed, however they’ve all been unfavorable.

“We imagine that solely sure sufferers with Alzheimer’s dementia could profit from statins and that earlier medical trials have been too small to indicate any important variations. “Our thought is to attempt to crystallize which affected person teams profit probably the most and why, earlier than embarking on medical trials,” says Sara Garcia-Ptacek.

The analysis was funded by Area Stockholm, the Swedish Analysis Council and the Dementia and Margareta af Ugglas Basis.

Supply:

Journal reference:

Petek, B., et al. (2023) Statins and cognitive decline in sufferers with Alzheimer’s and combined dementia: a longitudinal registry-based cohort examine. Alzheimer’s Analysis & Remedy. doi.org/10.1186/s13195-023-01360-0.

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