On this interview with NewsMedical, Dr. Yousef Nazirizadeh provides insights into the superior functionalities and numerous sorts of Byonoy’s plate readers, underscoring their significance within the business.

What impressed Byonoy to problem business norms in laboratory instrumentation, significantly within the realm of plate readers?

query to start out with! We’ve been impressed by developments within the shopper items business which have considerably improved the convenience of use and high quality of merchandise during the last 15 to twenty years. We realized how vital these options are for everybody and recognized a niche within the laboratory tools business. Subsequently, we’re centered on elevating the requirements of high quality and value and reenvision laboratories.

Our objective is to interrupt with outdated lab conventions and create an setting the place researchers can deal with their functions somewhat than being bothered by the instruments they use. We imagine that by integrating these rules, we will contribute to a contemporary change in the best way laboratories work, which in the end promotes effectivity and scientific innovation.

How does Byonoy’s dedication to democratizing measurement know-how positively influence researchers and laboratories?

Democratization within the context of laboratory tools means larger decentralization. Historically, labs have relied on multimode readers, that are highly effective however usually costly and restricted to centralized amenities. In these centralized labs, researchers should go to a selected location to achieve entry to the required tools, which will be each inconvenient and restrictive.

Our method challenges this establishment. We provide small, versatile, single-mode readers designed to be used in any lab, both on the researcher’s workbench or outdoors in a discipline lab. By bringing the gadgets nearer to the consumer, we goal to decentralize the workflow in order that researchers are now not solely depending on central laboratories.

Not solely portability but additionally affordability is a vital side of our technique. We offer researchers with entry to high-quality laboratory tools and be certain that price isn’t a barrier to scientific breakthroughs.

Picture Credit score: Byonoy

Beginning with the Absorbance 96 microplate reader, might you define its key options and distinctive elements of the machine?

Our devices are designed for flexibility and ease of use. Take the Absorbance 96, for instance – it is a compact absorbance microplate reader that can be utilized in quite a lot of laboratory environments, together with benchtops, anaerobic chambers, and discipline stations. This versatility opens up new potentialities for experiments.

To realize the compactness of our devices, we’re utilizing a solid-state know-how with 96 particular person detection models – a big departure from the traditional scanning mechanisms present in conventional microplate readers. And compactness is not nearly saving area; it is our design philosophy that brings further advantages like low upkeep and robustness.

The Absorbance 96 Automate was the recipient of the 2023 SLAS New Product Award, congratulations! What performance does it supply, and the way does it seamlessly combine into laboratory automation workflows?

Thanks for the needs. Truly, Absorbance 96 Automate is an evolution of our unique Absorbance 96.

Many assays carried out on liquid dealing with programs or robotic platforms have a readout because the final step, which is often carried out with a microplate reader situated subsequent to the automated system. Our technique challenges this norm by shrinking the know-how to a measurement not a lot bigger than the microplate itself. This provides researchers entry to a microplate reader that’s instantly built-in into the liquid dealing with system, enabling seamless automated workflows.

With our resolution, there is no want for the steps of manually transferring the microplate for studying or redesigning the lab setup to accommodate the microplate reader close by. We’ve integrated grooves that facilitate the microplate reader and plate dealing with by way of built-in grippers. This enormously simplifies the combination course of and never solely saves beneficial on-deck area but additionally minimizes the price of further third-party {hardware} required for automated workflows.

Picture Credit score: Byonoy

Please might you share the imaginative and prescient that drove the event of your newest product, Luminescence 96?

The success of the Absorbance 96 was for us the validation of the concept of a compact, user-friendly, and inexpensive machine by the market and has strengthened our product improvement. Constructing on this momentum, we needed to additional develop our vary of high-quality plate readers for different measurement strategies similar to luminescence.

With Luminescence 96, now we have taken one other leap ahead by additional innovating and enhancing numerous elements when it comes to know-how and ease of use. In contrast to different luminometers that require handbook changes similar to integration time and acquire, with Luminescence 96 now we have simplified your entire workflow. Our machine takes care of those parameters internally and units them robotically primarily based on the particular assay.

Picture Credit score: Byonoy

How did your staff overcome the challenges in creating Luminescence 96, successfully uniting compactness with top-tier efficiency?

Good query! In Luminescence 96 we’re breaking new floor in detection know-how. We’ve moved away from the traditional use of huge photomultiplier tubes and have built-in extremely delicate and smaller silicon photomultipliers. It is a vital step for luminometers, as these silicon photomultipliers haven’t been utilized in microplate readers earlier than. However to have the ability to use these detectors, we needed to reinvent the microplate luminometer. We’ve made numerous innovations, which now we have additionally registered for patents.

What are a number of the benefits? Is it simply when it comes to compactness, or are there efficiency advantages?

Crosstalk, dynamic vary, and background phosphorescence are main challenges for such gadgets. We’ve exceeded the business commonplace in all these areas.

As a consequence of their ultra-compact measurement, the proximity of those detectors to the wells is a sport changer, nearly eliminating crosstalk. As well as, to maximise the dynamic vary of our silicon photomultipliers, we make use of three subtle readout strategies: photon counting, integration, and micro-integration, enabling us to increase the linear dynamic vary as much as 8 a long time. And to eradicate background phosphorescence, we use personalized IR filters.

How does Luminescence 96 make superior luminometers extra inexpensive and accessible to a wider vary of laboratories?

We imagine in bringing superior instrumentation to a broader spectrum of the scientific neighborhood. To realize this, we apply first-principles pondering all through the instrument improvement course of. On this approach, we do not simply present modern options, we actively contribute to a change that permits laboratories of all sizes to have entry to cutting-edge know-how.

What lies forward for Byonoy when it comes to product improvement and increasing its product vary? Are there any upcoming improvements or initiatives that you’re significantly enthusiastic about?

Whereas I am unable to reveal all the main points of our upcoming merchandise, I can inform you that now we have a number of thrilling concepts within the pipeline.

For instance, there’s a rising demand for a fluorescence reader and this space is of nice curiosity to us. We encourage everybody to remain tuned as we discover new frontiers, and we sit up for unveiling what’s subsequent on our journey of innovation and exploration.

About Yousef Nazirizadeh

Dr. Yousef Nazirizadeh holds a Ph.D. diploma in nanophotonics and biophotonics from Karlsruhe Institute of Know-how (KIT) Germany. Fueled by a ardour for multidisciplinary innovation and purposeful interface designs, Dr. Nazirizadeh co-founded Byonoy with the objective of creating high-end devices for analysis. Combining his years of scientific experience and entrepreneurial spirit, he leads because the CEO of Byonoy and oversees the corporate’s analysis and improvement efforts.

About Byonoy

Byonoy is an rising biotech firm specializing within the manufacture of microplate readers for 96-well functions. Byonoy’s distinctive technical options have enabled them to create a brand new era of plate readers with an ultra-compact footprint, disrupting the requirements for instrument measurement. This new, compact design permits for versatile use inside the laboratory, simplifying the workflow whereas giving the consumer new potentialities. With a eager eye for rising applied sciences, Byonoy goals to stay on the forefront of microplate reader improvement, making use of its distinctive options to varied detection strategies.

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