Home Men's Health Research identifies key markers for early detection of fatty liver illness in overweight and non-obese people

Research identifies key markers for early detection of fatty liver illness in overweight and non-obese people

Research identifies key markers for early detection of fatty liver illness in overweight and non-obese people


In a current research printed within the journal Scientific Studiesresearchers examine whether or not insulin- and non-insulin-based insulin resistance (IR) markers might predict the chance of non-alcoholic fatty liver illness (NAFLD) in overweight and non-obese people with no historical past of diabetes or hepatitis.

Study: Markers of insulin resistance associated with non-alcoholic fatty liver disease in non-diabetic population. Image Credit: Jo Panuwat D / Shutterstock.com Research: Markers of insulin resistance related to non-alcoholic fatty liver illness in non-diabetic inhabitants. Picture Credit score: Jo Panuwat D / Shutterstock.com


Presently, liver biopsy, which is the gold customary diagnostic check for non-obese NAFLD, is invasive, whereas different strategies, equivalent to magnetic resonance imaging (MRI) and computed tomography (CT), are costly. Though ultrasound imaging is comparatively cheap, it’s poorly delicate to gentle steatosis, and completely different physicians interpret its outcomes otherwise. General, there’s a scarcity of applicable diagnostic strategies for detecting atypical non-obese NAFLD. 

Earlier research have evaluated the affiliation between IR markers and the chance of NAFLD; nonetheless, most have generated inconsistent outcomes. However, IR markers might help within the early detection of NAFLD in non-obese sufferers with larger precision, given their affiliation with liver fibrosis in NAFLD sufferers with out diabetes.

In regards to the research

Within the current research, researchers recruited 2,148 topics between 2021 and 2023 and picked up info concerning their gender, age, in addition to present and previous medical and drugs historical past. Primarily based on computed physique mass index (BMI), the research members had been categorized as non-obese or overweight, with BMI values of lower than 25 kg/m2 and exceeding 25 kg/m2, respectively.

Venous blood samples had been collected after the research members accomplished a minimum of 10 hours of fasting. The degrees of 4 non-insulin-based IR markers had been assessed, which included homeostatic mannequin evaluation of IR (HOMA-IR), triglyceride-glucose (TyG) index, TyG index with BMI (TyG-BMI), and triglyceride/high-density lipoprotein ldl cholesterol ratio (TG/HDL-c), in addition to metabolic rating for IR (METS-IR). The degrees of those biomarkers had been in contrast for his or her predictive capability for overweight and non-obese NAFLD.

Logistic regression fashions had been used to evaluate the connection between IR markers and NAFLD threat. IR marker values had been categorized into 4 quartiles of various variables.

The realm below the curve (AUC) and receiver working attribute (ROC) values allowed the researchers to judge the predictive capability of IR markers for NAFLD. In distinction, the chances ratio (OR) and 95% confidence interval (CI) had been used to quantify the correlation between IR markers and NAFLD threat. The statistical significance threshold was set at a p-value of lower than 0.05.

Research findings

The NAFLD group had considerably elevated ranges of fasting plasma glucose (FPG), uric acid (UA), TG, aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transpeptidase (GGT). Notably, the BMI of the overweight and non-obese subgroups of the NAFLD group was additionally considerably larger.

The ORs for all 5 IR markers, together with HOMA-IR, TyG, TyG-BMI, TG/HDL-c, and METS-IR, had been markedly larger within the NAFLD group than within the non-NAFLD group. These ranges typically elevated with rising ranges of quartiles within the general research cohort, in addition to amongst overweight and non-obese subgroups. 

Within the non-obese subgroup, the AUC of TyG-BMI was the very best, thus suggesting that TyG-BMI has a greater predictive worth for NAFLD in non-diabetic and non-obese sufferers. Comparatively, within the overweight subgroup, the AUC of HOMA-IR was the very best, which signifies that HOMA-IR is a greater predictor for NAFLD in non-diabetic overweight topics. Furthermore, the AUC of every IR marker was over 0.5 with p-values lower than 0.05, thus indicating statistically important and particular predictive values for NAFLD. 


The research findings corroborate earlier stories of IR markers related to an elevated threat of NAFLD. Thus, utilizing TyG-BMI and HOMA-IR IR markers look like clinically related for diagnosing non-obese and overweight NAFLD, respectively, as they had been related to higher detection talents than the opposite IR markers.

Though the researchers couldn’t make clear the rationale for this distinction, they speculate that since TyG-BMI is calculated primarily based on physique fats distribution utilizing FPG, TG, and BMI values, it has superior diagnostic worth in non-obese people. However, a number of research additionally counsel that standard BMI in non-obese sufferers stays an impartial threat issue for NAFLD.

Journal reference:

  • Zeng, P., Cai, X., Yu, X., & Gong, L. (2023). Markers of insulin resistance related to non-alcoholic fatty liver illness in non-diabetic inhabitants. Scientific Studies 13(1); 1-8. doi:10.1038/s41598-023-47269-4



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