Home Men's Health Prunes pack a robust punch towards irritation and bone loss in postmenopausal ladies

Prunes pack a robust punch towards irritation and bone loss in postmenopausal ladies

Prunes pack a robust punch towards irritation and bone loss in postmenopausal ladies


A brand new research printed in The Journal of Vitamin exhibits day by day consumption of prunes could cut back irritation markers linked to bone signaling pathways and cut back the results of bone loss amongst postmenopausal ladies.

Prunes pack a powerful punch against inflammation and bone loss in postmenopausal women
California Prunes are nutritious and versatile. Picture Credit score: California Prune Board

Bone loss is a big challenge impacting greater than 50% of ladies over the age of fifty, and there’s no treatment. Whereas medicines and hormone therapies can be found, they typically require lifelong administration and include dangers. It’s necessary to have a greater understanding of how non-pharmacological approaches – like way of life and dietary decisions—may influence the development and mitigation of bone loss.”

Principal Investigator Mary Jane De Souza, Professor, Division of Kinesiology, Pennsylvania State College

The brand new research’s findings present important reductions in inflammatory cytokines, that are proteins that assist management irritation, and activated monocytes, that are a significant sort of immune cell that has been proven to drive the continual inflammatory response, when 50 to 100 grams of prunes (about 5-12 prunes) are included within the weight loss plan, day by day. Particularly, reductions have been seen in Tumor Necrosis Issue-α following 50 grams of day by day prune consumption, and reductions in Interleukin-1β, Interleukin-6, Interleukin-8 secretions, in addition to activated monocytes, with 100 grams of prune consumption, in comparison with diets with out prunes.

“These findings could also be attributed to the abundance of bioactive compounds present in prunes, together with nutritional vitamins, minerals, phenolic acids and polyphenols, that are doubtless performing synergistically to suppress activated monocytes and their secretion of bone-resorptive inflammatory cytokines,” stated Co-author Connie Rogers, PhD, MPH, Professor and Division Head, Division of Dietary Sciences, College of Georgia.

That is an ancillary research of a bigger, single-center, parallel-arm, 12-month randomized management trial (PRUNE research). The PRUNE research aimed to discover immune, inflammatory and oxidative stress markers associated to the bone-protective results of prunes in nonsmoking and never severely overweight postmenopausal ladies, aged 55-75 years who shunned phenolic dietary supplements or massive quantities of phenolic-containing fruit (apples and blueberries) for a minimum of 2 months previous to the beginning of the research. This investigation was accomplished by 183 contributors who have been cut up into three teams: management/no prunes (n=70), 50 grams/day prunes (n=67) and 100 grams/day prunes (n=46). After a run-in interval, contributors adopted the prune protocol for a complete of 12-months and have been instructed to file the times and variety of prunes eaten in a day by day log, used to watch compliance. Individuals have been thought of compliant in the event that they consumed greater than 80% of their prescribed remedy, and all contributors consumed extra 90% of their prescribed remedy.

Measurements of immune, inflammatory and oxidative stress markers have been taken at baseline and on the finish of the 12-month intervention. Past the prune consumption protocols, all contributors obtained a day by day dose of calcium and vitamin D3 to satisfy the advisable dietary allowance of 1200 mg of calcium and 800 IU vitamin D3 day by day from weight loss plan plus dietary supplements, they usually adopted a free-living weight loss plan.

“These findings add to a rising physique of analysis and curiosity investigating the function of ‘meals as medication’ and complement different research I’ve carried out utilizing the identical information,” De Souza stated. “For instance, the earlier research I led confirmed connections between hip bone integrity and day by day consumption of prunes—the place postmenopausal ladies who didn’t eat prunes misplaced 1.5% of their hip bone density in comparison with ladies who ate 5-6 prunes day by day. Collectively, these findings have important sensible significance given the prevalence of bone loss amongst this inhabitants.”

“Our funding within the PRUNE research has led to many key publications and novel findings that may assist enhance public well being and the understanding of the function meals could play in illness prevention and administration,” stated Donn Zea, govt director, California Prune Board. “We’re deeply dedicated to the scientific rigor of our vitamin analysis program which gives a license to speak how having fun with California Prunes can affect well being outcomes.”

For about 100 energy, a serving of 4-6 California Prunes is a nutrient-dense superfood offering greater than 20 totally different nutritional vitamins, minerals, and plant compounds to the weight loss plan. As a premium dried fruit loved throughout cultures and ethnicities, analysis into California Prunes’ well being advantages contributes to a greater understanding of their function as a dietary instrument to advertise well being and doubtlessly decrease continual illness danger.


Journal reference:

De Souza, M. J., et al. (2022). Prunes protect hip bone mineral density in a 12-month randomized managed trial in postmenopausal ladies: the Prune Examine. The American Journal of Medical Vitamin. doi.org/10.1093/ajcn/nqac189.



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