Home Men's Health How dietary restrictions, together with intermittent fasting, impression intestine microbiota and total human well being

How dietary restrictions, together with intermittent fasting, impression intestine microbiota and total human well being

How dietary restrictions, together with intermittent fasting, impression intestine microbiota and total human well being


In a latest evaluate printed in Vitamins, researchers reviewed preclinical and scientific knowledge to investigate intestine microbial alterations in numerous dietary circumstances.

Study: The Beneficial Effects of Dietary Interventions on Gut Microbiota—An Up-to-Date Critical Review and Future Perspectives. Image Credit: LightField Studios/Shutterstock.comExamine: The Useful Results of Dietary Interventions on Intestine Microbiota—An Up-to-Date Essential Evaluate and Future Views. Picture Credit score: LightField Studios/Shutterstock.com


Intermittent fasting (IF), a well-liked dietary intervention, has been studied for its impression on intestine microbial composition and host physiopathological processes.

Research present that eating regimen constituents modulate the intestine microbial group, and the nutrient transformations in microbes deeply affect host metabolism.

This reciprocal affiliation may doubtlessly have an effect on the metabolism of continual medicine, considerably affecting human well being and illness. Dietary interventions for numerous issues may very well be tailor-made to enhance total well being by restoring the intestine microbial steadiness and variety.

Concerning the evaluate

Within the current evaluate, researchers described the impression of eating regimen on the intestinal microbiome by reviewing preclinical and scientific research printed within the PubMed database in English from 2015 to 2023. For preclinical knowledge, solely research printed between 2021 and 2023 had been included.

Two researchers independently carried out knowledge screening, and discrepancies had been resolved by consensus. Protocols, research, and case studies with inaccessible full textual content had been excluded, and eligible information underwent full-text screening. In complete, 17 preclinical information and 26 scientific information had been analyzed.

Preclinical research relating to the consequences of dietary intervention on the intestine microbiota of animals

In six-week-old C57BL/6J mice, high-fat eating regimen (HF) and CR interventions elevated Firmicutes, Actinobacteria, Firmicutes: Bacteroidetes ratio, Bifidobacteriaceae, Lactobacillus johnsonii, Bifidobacterium pseudolongum, and Faecalibaculum abundance within the cecum. Nevertheless, these interventions decreased Bacteroidetes and Parabacteroides counts.

In male Fisher 344 x Brown Norway hybrid F1 rats, time-restricted feeding (TRF) Keto diets diminished fecal Actinobacteria and Patescibacteria counts and elevated Verrucomicrobia counts. Western eating regimen TRF (16:8) diminished fecal Bacteroidota, Proteobacteria, and Cyanobacteria counts whereas rising Verrucomicrobia counts.

Common chow eating regimen TRF elevated Lactobacillus, Muribaculaceae, Dubosiella, Clostridia, and Faecalibacterium counts. Mom submitted to intermittent fasting (M-IF) feed diminished Lactobacillus intestinalis abundance in mice offspring.

In male Wistar rats, IF diminished Firmicutes: Bacteroidetes ratio and Bacillus velezensis counts, elevated Lachnospiraceae and Lactobacillaceae counts, and elevated Lactobacillus and Akkermansia muciniphila counts. CR and IF elevated Helicobacter, Bacteroidetes, and Firmicutes counts in rainbow trout whereas lowering Actinobacteria counts within the proximal gut.

A 16:8 and 24:24 IF intervention elevated the abundance of varied microorganisms within the feces of allergic mice whereas lowering Firmicutes counts. Quick-term IF diminished Firmicutes, Verrucomicrobia, Lachnospiraceae, Ruminococcaceae, and Ruminiclostridium counts in C57BL/6 mice with induced colitis, whereas long-term IF diminished Akkermansiaceae and elevated Lactobacillaceae counts.

Preclinical research on intestine microbial composition in C57BL/6J mice discovered it adaptive to dietary modifications. Nevertheless, the outcomes lacked coherence and homogeneity relating to bacterial strains/group dynamics.

Several types of fasting produce other influences on intestine microbes, and drawing inferences is difficult because of the research protocols involving numerous feeding restrictions, durations, and diets. As well as, assessments had been carried out on a number of animal fashions, which may very well be particularly delicate to calorie restriction (CR).

Results of dietary interventions on the human intestine microbiota

A randomized managed trial (RCT) reported that Buchinger fasting for 5 days elevated Proteobacteria and Christensenellaceae counts however diminished Firmicutes: Bacteroides ratio. Water-only fasting diminished Fusobacterium counts and elevated homogenous intestine microbiota.

Ramadan intermittent fasting elevated alpha range, Lachnospiraceae, and Ruminococcaceae counts however decreased Bacteroidales. In different research, Ramadan intermittent fasting diminished Coprococcus, Clostridium_XlV spp., and Lachnospiraceae counts however elevated Dorea, Klebsiella, Faecalibacterium, Sutterella, Parabacteroides, Alistipes, Bacteroides, and Firmicutes counts.

Ten days of Buchinger fasting and three months of refeeding diminished Firmicutes counts however elevated Bacteroides, Proteobacteria, and Bacteroides. Buchinger fasting adopted by a Mediterranean-like eating regimen for hypertensive sufferers with metabolic syndrome can cut back Bifidobacterium, Coprococcus comes, and Roseburia counts.

In overweight postmenopausal ladies, VLCD for 46 days will increase Christensenellaceae counts. In chubby and overweight adults, a six-week caloric restriction and weight stabilization eating regimen reduces Akkermansia muciniphila counts.

Dietary restriction can impression the intestine microbiota by lowering proinflammatory cytokines, enhancing short-chain fatty acid (SCFA) manufacturing, rising intestinal barrier integrity, and exhibiting immunomodulatory results.

Lengthy-term dietary restriction for a yr diminished Actinobacteria counts and Firmicutes: Bacteroidetes ratio whereas rising Bacteroides, Roseburia, Faecalibacterium, and Clostridium XIVa ratio. No distinct sample of intestine microbiota modifications was established; nonetheless, well being advantages had been evident, together with diminished threat components for age-related ailments and elevated lifespan.

Based mostly on the evaluate findings, dietary interventions like time-restricted fasting and caloric restriction have been studied for his or her impression on metabolic well being markers and intestine microbiota composition. These packages alter the intestine atmosphere by altering nutrient availability, power sources, microbial development, and SCFA manufacturing.

They’ll lower irritation, regulate metabolism, and enhance circadian rhythm. Nevertheless, knowledge is inadequate to ascertain a typical sample of intestine microbiota modifications.

Additional analysis is required, particularly on overweight and metabolically compromised sufferers, to establish long-lasting modifications and assess completely different intestine microbiota molecules.



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