Home Men's Health Examine hyperlinks elevated BMI to weaker immune response post-SARS-CoV-2 an infection

Examine hyperlinks elevated BMI to weaker immune response post-SARS-CoV-2 an infection

Examine hyperlinks elevated BMI to weaker immune response post-SARS-CoV-2 an infection


In a latest research revealed in Clinic & Translational Immunology, researchers evaluated the impression of physique mass index (BMI) elevation on humoral immunity ranges towards extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Study: Elevated BMI reduces the humoral response to SARS-CoV-2infection. Image Credit: Brastock/Shutterstock.com
Examine: Elevated BMI reduces the humoral response to SARS-CoV-2 an infection. Picture Credit score: Brastock/Shutterstock.com


The worldwide morbidity and mortality from the coronavirus illness 2019 (COVID-19) has been extreme, with reinfection charges pushed by reducing immunity and variations of concern. Antibody-based immunity is crucial to stop reinfection with SARS-CoV-2. Reminiscence B lymphocytes are essential for ample humoral immunity towards SARS-CoV-2 and safety towards reinfection.

Upon reinfection with SARS-CoV-2, reminiscence B lymphocytes quickly convert to plasma cells to supply high-affinity neutralizing antibodies. Circulating antibody ranges throughout reinfection modulate illness threat.

Nevertheless, there may be restricted information to establish host variables linked to vulnerability and humoral response impairment. Weight problems has been linked to an enhanced threat of COVID-19 severity and reinfection; nonetheless, its impression on humoral immunity to vaccination and SARS-CoV-2 an infection is unknown.

In regards to the research

Within the current research, researchers investigated whether or not an elevated BMI (BMI equal to or above 25 kg/m2) may weaken antibody-based immunity towards SARS-CoV-2.

The crew obtained serum samples from COVID-19 convalescent Brisbane residents inside three months (first go to) to 13.0 months (second go to) of acute an infection in March 2020 (no SARS-CoV-2 publicity or vaccination within the interval). They evaluated humoral safety towards SARS-CoV-2, grouping people by BMI above or beneath 25 kg/m2.

The crew additionally obtained serum samples from Melbourne residents 5 months after the second SARS-CoV-2 vaccination (most of whom had no COVID-19 historical past) to research whether or not there was an affiliation between elevated physique mass index (equal to or above 25.0 kg/m2) and antibody responses to vaccination.

The full anti-SARS-CoV-2 spike-targeted antibodies [half-maximal effective concentration (EC50), neutralization capacity [half-maximal inhibitory concentration (IC50)], avidity, cross-strain neutralization, and antibody-dependent cell-mediated cytotoxicity (ADCC) had been assessed between the visits utilizing a paired evaluation of matched samples to guage the impression of physique mass index on the sturdiness of antibody responses post-infection.

The crew assessed the SARS-CoV-2 ancestral pressure and Delta variant neutralization. They assessed reminiscence B lymphocytes to find out the impression of physique mass index on decreased SARS-CoV-2 neutralization post-infection. At every go to, they in contrast humoral responses between people with decrease and better physique mass index values. Weighted a number of linear regression modeling was carried out for evaluation.


Elevated BMI (equal to or above 25 kg/m2), contemplating gender and age variations, was linked to attenuated humoral responses towards SARS-CoV-2. Three months post-infection, elevated physique mass index was correlated with decrease serum antibody titers. 13 months post-acute SARS-CoV-2 an infection, elevated BMI was associated to decrease SARS-CoV-2 spike-targeted B lymphocyte counts and decrease antibody avidity.

Contrastingly, there have been no important associations between BMI ≥25 kg/m2 and antibody-based immunity towards SARS-CoV-2 after 5 months of secondary COVID-19 vaccination. The crew noticed a major discount in EC50 titers over time in each teams with out avidity variations. Nevertheless, people with elevated BMI skilled ADCC discount over time, whereas low-BMI people didn’t. The researchers noticed a statistically important discount in IC50 titers towards the SARS-CoV-2 Wuhan-Hu-1/ancestral pressure and the Delta variant over time solely amongst members with the next BMI. There have been no important reductions in SARS-CoV-2 spike-targeted and complete memory-type B lymphocytes with time in low-BMI or high-BMI cohorts.

People with increased BMI values had been older than their low-BMI counterparts. On the first go to, males confirmed considerably decrease antibody avidity in comparison with ladies, adjusting for age and BMI. Likewise, on the first go to, older age was related to considerably increased IC50 (Wuhan-Hu-1 pressure) and EC50 values adjusting for gender and physique mass index.

Contrastingly, physique mass index elevations led to remarkably decrease EC50 titers on the first go to, adjusting for intercourse and age. On the second go to, BMI was the one issue considerably related to modifications in humoral responses, the place elevated physique mass index was associated to decrease tetramer-positive B lymphocyte counts and decrease antibody avidity.

There have been no important variations in age, time post-second vaccination dose, or vaccination kind between people with the next and decrease BMI. Nevertheless, there have been statistically important variations within the intercourse distribution between each teams.

There was no distinction within the proportion of people with anti-SARS-CoV-2 nucleocapsid (N) immunoglobulin G (IgG) titers in each teams. In distinction to the immune responses post-infection, no important distinction was noticed in humoral immune responses to vaccination by age, gender, or BMI.


Total, the research findings confirmed an affiliation between elevated BMI and decreased antibody-based safety towards SARS-CoV-2. The weakening of SARS-CoV-2 infection-induced immunity amongst people with BMI ≥25 kg/m2 underpins the necessity for COVID-19 vaccination quite than counting on SARS-CoV-2 infection-induced immunity.

Journal reference:

  • Tong, M. Z., Sng, J. D., Carney, M., Cooper, L., Brown, S., Lineburg, Ok. E., Chew, Ok. Y., Collins, N., Ignacio, Ok., Airey, M., Burr, L., Joyce, B. A., Jayasinghe, D., McMillan, C. L., Muller, D. A., Adhikari, A., Gallo, L. A., Dorey, E. S., Barrett, H. L., Gras, S., Smith, C., Good‐Jacobson, Ok. and Brief, Ok. R. (2023) Scientific & Translational Immunology, 12(12). doi: 10.1002/cti2.1476https://onlinelibrary.wiley.com/doi/10.1002/cti2.1476



Please enter your comment!
Please enter your name here