Home Men's Health Citrus complement might ease knee swelling and ache after surgical procedure

Citrus complement might ease knee swelling and ache after surgical procedure

Citrus complement might ease knee swelling and ache after surgical procedure


For sufferers present process complete knee arthroplasty (TKA), therapy with diosmin – a flavonoid complement derived from citrus fruits –lowered swelling of the knee and leg and a few measures of related ache may be achieved, experiences a scientific trial in The Journal of Bone & Joint Surgical procedure. The journal is revealed within the Lippincott portfolio in partnership with Wolters Kluwer.

“The usage of diosmin after TKA lowered lower-extremity swelling and ache throughout movement and was not related to an elevated incidence of short-term issues involving the outcomes studied,” in response to the brand new analysis by Pengde Kang, PhD, MD, of Sichuan College, Chengdu, China, and colleagues.

Potential new method to alleviate painful swelling after TKA

Swelling is a standard drawback in sufferers present process TKA, and one which contributes to ache and affected person dissatisfaction. “Postoperative lower-extremity swelling is a serious hindrance to the improved restoration of sufferers present process TKA,” the researchers write. Varied measures have been proposed to lower swelling, together with relaxation, chilly packs, and compressive bandages, with blended success. Presently, there are not any efficient treatment selections to cut back swelling after TKA.

Diosmin – usually together with a associated flavonoid known as hesperidin – has been used to cut back swelling of the limbs in sufferers with venous problems. Though diosmin isn’t authorised as a prescription treatment in the US or Europe, expertise means that it’s nicely tolerated with low toxicity. Based mostly on these traits, the researchers designed a scientific trial to guage the effectiveness and security of diosmin in sufferers present process TKA.

The exploratory research included 330 sufferers present process TKA at 13 university-affiliated hospitals. Sufferers have been randomly assigned to both a therapy group, receiving a 14-day course of diosmin beginning postoperative day 1; or to a management group, receiving no research therapy. Each teams acquired normal ache medicines.

Swelling at particular places was measured at 1, 2, 3, and 14 days postoperatively and in contrast between the diosmin and management teams. Ache scores, knee perform, complication charges, and blood ranges of sure inflammatory markers (C-reactive protein and interleukin-6) have been additionally assessed.

Diosmin reduces swelling and ache scores with motion

The outcomes confirmed lowered swelling on the knee, calf, and thigh as much as 14 days after TKA in sufferers assigned to diosmin. The discount in swelling was related to decrease ache scores on knee motion. In distinction, ache scores at relaxation weren’t considerably totally different for the diosmin versus management teams. Assessments of knee perform restoration and ranges of inflammatory biomarkers have been related as nicely.

Quick-term complication charges have been additionally related between teams, supporting the protection of diosmin. Thsere was a pattern towards decreased charges of postoperative nausea and vomiting with diosmin, though the distinction was not important.

The research offers preliminary proof that diosmin is a secure and efficient therapy to cut back swelling and ache with motion after TKA. Nonetheless, questions stay as to how diosmin exerts these results – notably because the research finds no change in inflammatory biomarker ranges between teams.

“This detrimental end result might replicate the efficacy of the opposite anti-inflammatory medication that have been administered to each teams,” Dr. Kang and colleagues write. They emphasize the necessity for additional research to evaluate the mechanism by which diosmin reduces swelling, and whether or not some various dosing routine is perhaps more practical.


Journal reference:

Wang, Q., et al. (2021). Efficacy of Diosmin in Decreasing Decrease-Extremity Swelling and Ache After Complete Knee Arthroplasty: A Randomized, Managed Multicenter Trial. The Journal of Bone and Joint Surgical procedure​. doi.org/10.2106/JBJS.23.00854.



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